Comparative 3D genome organization in apicomplexan parasites Significance From yeast to human cells, genome organization in eukaryotes has a tight relationship with gene expression. We investigated the 3D organization of chromosomes in malaria parasites to identify possible connections between genome architecture and pathogenicity. Genome organization was dominated by the clustering of Plasmodium-specific gene families in...

An international research team led by scientists at the University of California, Riverside, and the La Jolla Institute for Immunology has found that malaria parasite genomes are shaped by parasite-specific gene families, and that this genome organization strongly correlates with the parasite’s virulence. The findings highlight the importance of spatial genome organization in gene regulation...